Why is monoclonal antibody stability so important?
Monoclonal antibodies (mAbs) are an increasingly important aspect of drug development. As the concentration of protein in therapeutic mAb formulations is becoming rather high, stability is more of an issue.
Antibody Selection using DNA Origami Scaffolds
Humans have different types of antibodies, such as the Immunoglobulins G (IgG) and M (IgM). IgG is the antibody class which is the most abundant in blood, while IgM is usually the antibody class that first occurs after the immune system is challenged by a new antigen.
An easier way of sneaking antibodies into cells
For almost any conceivable protein, corresponding antibodies can be developed to block it from binding or changing shape, which ultimately prevents it from carrying out its normal function.
How Mass Spectrometry Can Help Limit Reproducibility Problems
Antibodies are critical for biological and medical research. Yet, since early 2015, the state of the antibody industry has been described as being in a reproducibility crisis.